It is surprising and sometimes annoying when people state categorically and definitively that cyclizine and metoclopramide antagonise each other. Cyclizine acts centrally on H1, M1, M2 and M3 receptors and Metoclopramide acts both centrally and peripherally on D2 and M1 receptors. Theoretically, there may be competitive inhibition of the one or other at M1 receptors without clinical effect.
These antiemetics do not "block each other" or "cancel each other out".
No comments:
Post a Comment